Genetic causes of gene expression variation in Arabidopsis thaliana

Speaker: Philipp Drewe , Memorial Sloan–Kettering Cancer Center

Date: Wednesday, October 09, 2013

Time: 9:00 AM to 10:30 AM Note: all times are in the Eastern Time Zone

Refreshments: 9:00 AM

Public: Yes

Location: 32-G449 (Patil/Kiva)

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Host: Manolis Kellis

Contact: derek aylward, 6177154882, derekaylward@csail.mit.edu

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Reminders to: kellislab@mit.edu

Reminder Subject: TALK: Philipp Drewe, Genetic causes of gene expression variation in Arabidopsis thaliana

Understanding the genetic basis for gene expression variations has come into reach with the availability of high throughput genotyping and gene expression quantification. The richness of these data sources rendered genome-wide association of genetic variation with gene expression variation possible. However the identification of the causal variants and their mechanism of action is still challenging.
In this work we focus on the role of transcription factors in mediating gene expression variation. To do this this we analyze an artificial population of 200 Arabidopsis thaliana strain. We show that integration of transcription factor binding, genotype and gene expression information helps identify causal genetic variants. Furthermore we dissect the contributions of cis- and trans-variation of transcription factors on gene expression variation.

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Created by derek aylward Email at Wednesday, September 25, 2013 at 1:33 PM.