- Regulation of Apoptotic Cas...
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Regulation of Apoptotic Cascades by the N-end Rule Proteolytic Pathway
Speaker:
Dr. Konstantin Piatkov
, Division of Biology, California Institute of Technology
Date: Friday, November 15, 2013
Time: 11:00 AM to 12:00 PM Note: all times are in the Eastern Time Zone
Refreshments: 10:45 AM
Public: Yes
Location: 76-659
Event Type:
Room Description:
Host: Professor Bruce Tidor
Contact: Brett Minassian, 617-324-8169, brettm@mit.edu
Speaker URL: None
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Reminders to:
seminars@csail.mit.edu, csail-related@lists.csail.mit.edu
Reminder Subject:
TALK: Regulation of Apoptotic Cascades by the N-end Rule Proteolytic Pathway
Abstract:
I will discuss my research on a processive proteolytic system called the N-end rule pathway. Recently we found that this proteolytic pathway can selectively target a number of naturally produced proapoptotic fragments. Our findings indicate that the N-end rule pathway acts to counteract cell death through the degradation of proapoptotic protein fragments, thereby setting specific thresholds that prevent a transient or an otherwise weak apoptotic signal from reaching the point of commitment to apoptosis. In agreement with these results, we showed that even a partial genetic ablation of the N-end rule pathway sensitizes cells to apoptosis. We have also recently demonstrated that the N-end rule pathway selectively degrades specific neurotoxic protein fragments that have been implicated in neurodegenerative disorders, such as Alzheimer¹s disease, amyotrophic lateral sclerosis (ALS), and synucleinopathies, including Parkinson¹s disease.
These advances not only broadened our understanding of the cellular apoptotic defense mechanisms but also opened up new opportunities to pharmacologically manipulate apoptotic and inflammatory cascades.
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Created by Niranjala Manokharan at Wednesday, November 13, 2013 at 10:20 AM.