An Image-Based Analysis of the Mechanical Mediators of Osteoarthritis in the First Carpometacarpal Joint

Speaker: Eni Halilaj , Brown University

Date: Wednesday, April 09, 2014

Time: 3:00 PM to 4:00 PM Note: all times are in the Eastern Time Zone

Public: Yes

Location: 32-G531

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Host: Polina Golland

Contact: Polina Golland, x38005,

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Reminder Subject: TALK: An Image-Based Analysis of the Mechanical Mediators of Osteoarthritis in the First Carpometacarpal Joint

The opposability of the human thumb is attributable to the
saddle geometry of first carpometacarpal (CMC) joint. Paradoxically, the
same geometry that allows versatility is often cited as responsible for
mechanical instability and the high incidence of osteoarthritis (OA) in
this joint. CMC OA is a degenerative disease of cartilage and bone that
affects women twice as frequently as men and whose incidence increases with
aging. While the etiology of CMC OA remains unknown, joint biomechanics is
thought to be implicated in its pathogenesis. The aim of our work has been
to use computed tomography (CT) imaging to determine if potential
differences in bony and soft-tissue morphology are related to
pathomechanics in the CMC joint. The first part of my talk will focus on
the application of polar histograms of curvature as shape descriptors for
articular joints and as integrants of a joint congruence metric. I will
present results from a population of 155 subjects showing evidence that,
contrary to a long-held belief, female joints are not shaped differently
from male joints and that they are not less congruent. I will then talk
about how we use sequential CT scans of the joint in different
physiological positions to determine joint kinematics and contact
mechanics, as well as to derive subject-specific models of cartilage and
ligaments. I will end with a summary of how the presented findings have the
potential to influence treatment options for CMC OA.

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See other events that are part of the Biomedical Imaging and Analysis 2013/2014.

Created by Polina Golland Email at Thursday, February 20, 2014 at 10:15 PM.