Drug design and delivery using cell-penetrating peptides: from atomistic models to living cells

Speaker: Dr. Henry David Herce

Date: Wednesday, May 31, 2017

Time: 4:00 PM to 5:00 PM

Refreshments: 3:45 PM

Public: Yes

Location: Star D463

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Host: Manolis Kellis, Kellis Lab, MIT, CSAIL

Contact: Geraldine McGowan, gmcgowan@csail.mit.edu

Relevant URL: www.hdherce.com, www.cell-penetrating-peptides.com

Speaker URL: None

Speaker Photo:
None

Reminders to: seminars@lists.csail.mit.edu

Reminder Subject: TALK: Drug design and delivery using cell-penetrating peptides: from atomistic models to living cells

Arginine-rich molecules, such as cell-penetrating peptides,
efficiently enter into living cells in a non-endocytotic
energy-independent manner transporting a wide range of cargoes,
including drugs and biomarkers. The mechanism by which these highly
cationic molecules efficiently cross the hydrophobic barrier imposed
by the plasma membrane has remained as a fundamental open question. I
will present a central mechanism based on a combination of
computational, in vitro and in vivo experimental evidence that reveals
an efficient energy-independent cellular uptake mechanism for
arginine-rich molecules. I will show how to apply these principles,
which appear to be universal across cells from different species and
kingdoms, to design, visualize and deliver antibodies, drugs and
biomarkers into living cells and organisms.

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This event is not part of a series.

Created by Geraldine McGowan at Wednesday, May 24, 2017 at 11:59 AM.