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Drug design and delivery using cell-penetrating peptides: from atomistic models to living cells
Speaker:
Dr. Henry David Herce
Date: Wednesday, May 31, 2017
Time: 4:00 PM to 5:00 PM Note: all times are in the Eastern Time Zone
Refreshments: 3:45 PM
Public: Yes
Location: Star D463
Event Type:
Room Description:
Host: Manolis Kellis, Kellis Lab, MIT, CSAIL
Contact: Geraldine McGowan, gmcgowan@csail.mit.edu
Relevant URL: www.hdherce.com, www.cell-penetrating-peptides.com
Speaker URL: None
Speaker Photo:
None
Reminders to:
seminars@lists.csail.mit.edu
Reminder Subject:
TALK: Drug design and delivery using cell-penetrating peptides: from atomistic models to living cells
Arginine-rich molecules, such as cell-penetrating peptides,
efficiently enter into living cells in a non-endocytotic
energy-independent manner transporting a wide range of cargoes,
including drugs and biomarkers. The mechanism by which these highly
cationic molecules efficiently cross the hydrophobic barrier imposed
by the plasma membrane has remained as a fundamental open question. I
will present a central mechanism based on a combination of
computational, in vitro and in vivo experimental evidence that reveals
an efficient energy-independent cellular uptake mechanism for
arginine-rich molecules. I will show how to apply these principles,
which appear to be universal across cells from different species and
kingdoms, to design, visualize and deliver antibodies, drugs and
biomarkers into living cells and organisms.
Research Areas:
Impact Areas:
Created by Geraldine McGowan at Wednesday, May 24, 2017 at 11:59 AM.