MIT Bioinformatics Seminar: Roded Sharan: Probabilistic and algebraic models for mutation data

Speaker: Roded Sharan, Tel-Aviv University

Date: Wednesday, March 30, 2022

Time: 11:30 AM to 1:00 PM Note: all times are in the Eastern Time Zone

Public: Yes

Location: https://mit.zoom.us/j/94668502175

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Host: Bonnie Berger

Contact: Jeffrey Taft, jmtaft@csail.mit.edu

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Reminders to: bioinfo-seminar@lists.csail.mit.edu, bergerlab-core@mit.edu

Reminder Subject: TALK: MIT Bioinformatics Seminar: Roded Sharan: Probabilistic and algebraic models for mutation data

ABSTRACT: Mutational processes shape the genomes of cancer patients, leaving distinct mutational signatures, and their understanding has important applications in diagnosis and treatment.
Current approaches for mutational signature discovery and analysis are based to a large extent on non-negative matrix factorization and make multiple assumptions about mutation category repertoire, data richness and independence of mutational processes. In this talk I will challenge each of these assumptions and present alternative probabilistic and algebraic models that can capture spatial dependencies among mutations, handle sparse data as typical in the clinic and derive informative mutation categories. The talk does not require previous biological background and will mainly emphasize the computational techniques involved.

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This event is not part of a series.

Created by Jeffrey Taft at Wednesday, March 23, 2022 at 5:16 PM.